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Nat Rev Drug Discov, Vol. 12, No. 7. (14 July 2013), pp. 543-559, doi:10.1038/nrd4025  Key: citeulike:12459256

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Abstract

Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation of the peripheral airways and lung parenchyma, which leads to progressive obstruction of the airways. Current management with long-acting bronchodilators does not reduce disease progression, and there are no treatments that effectively suppress chronic inflammation

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