By a News Reporter-Staff News Editor at Biotech Business Week — Investigators publish new report on Life Science Research. According to news originating from Brisbane, Australia, by NewsRx correspondents, research stated, “MicroRNAs (MiRNA) are small non-coding RNAs that regulate gene expression. The aim of this study was to identify miRNAs differentially expressed between mild and moderately emphysematous lung, as well as their functional target mRNAs.”
Our news journalists obtained a quote from the research from Prince Charles Hospital, “Resected lung from patients with COPD undergoing lung cancer surgery was profiled using miRNA (Agilent Human miRNA profiler G4470 V1.01) and mRNA (OperonV2.0) microarrays. Cells of lung origin (BEAS-2B and HFL1) were profiled using mRNA microarrays (Illumina HumanHT-12 V3) after in vitro manipulation. COPD patients had mean (SD) age 68 (6) years, FEV1 72 (17)% predicted and gas transfer (KCO) 70 (10)% predicted. Five miRNAs (miR-34c, miR-34b, miR-149, miR-133a and miR-133b) were significantly down-regulated in lung from patients with moderate compared to mild emphysema as defined by gas transfer (p
According to the news editors, the research concluded: “MiR-34c modulates expression of its putative target gene, SERPINE1, in vitro in respiratory cell lines and ex vivo in emphysematous lung tissue.”
For more information on this research see: MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression. Bmc Genomics, 2014;15():88. (BioMed Central – www.biomedcentral.com/; Bmc Genomics – www.biomedcentral.com/bmcgenomics/)
The news correspondents report that additional information may be obtained from S.M. Savarimuthu Francis, Dept. of Thoracic Medicine, The Prince Charles Hospital, Brisbane, QLD 4032, Australia. Additional authors for this research include M.R. Davidson, M.E. Tan, C.M. Wright, B.E. Clarke, E.E. Duhig, R.V. Bowman, N.K. Hayward, K.M. Fong and I.A Yang (see also Life Science Research).
Keywords for this news article include: Brisbane, Life Science Research, Australia and New Zealand.
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